Preparation and evaluation of red propolis and nystatin cyclodextrin inclusion complexes against oral microbiome opportunistic microorganisms

The human oral cavity is colonized by a diversity of microorganisms living harmoniously. When an imbalance occurs in this population, also called dysbiosis, opportunistic lead to infections. Nystatin, traditional antifungal, and red propolis, resinous mixture collected honeybees from plant source, can be used control Using ?-cyclodextrin (?CD) inclusion complexes with nystatin propolis may improve the solubility, stability antimicrobial activity these substances, making it possible include pharmaceutical formulations. This study aimed obtain solubilization characterize evaluate their against cavity. showed loss crystallinity infrared spectra interactions between substances. content total polyphenol ranged 4.32-4.62 mg/g, while flavonoids was 3.05-3.83 mg/g. (Prop):?CD(1:1 2:1) were most active S.aureus, S.epidermidis, S.mutans C.albicans Minimum Inhibitory Concentration (MIC) ranging 32-256 µg/mL. complex (Nys):?CD(1:1) effectively inhibited growth (MIC=4µg/mL). Interestingly, association Nys:?CD(1:1) Prop:?CD(1:1 or synergic effect, improving antifungal when compared alone.